New Publication: Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo

Using camelid-derived single-domain antibodies (VHH or nanobody) targeting the adaptor protein ASC, our team has recentlydemonstrated the role of post-pyroptotic ASC specks in the development ofpro-inflammatory diseases. VHH_ASC disrupt post-pyroptoticspecks – that is, either inside pyroptotic cells or once released from dyingcells – and prevent the unwanted perpetuation of inflammation that theytrigger.

Read more here: https://doi.org/10.15252/emmm.202115415

Press release: https://www.uni-bonn.de/en/news/075-2022

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Image: The team was also invited to design the journal cover in collaboration with EMBO Press!