Eicke Latz Lab Publications

ScienceTeamPublicationsAlumni

All Publications

Selected publications

Mitochondrial damage activates the NLRP10 inflammasome.

Próchnicki T, Vasconcelos MB, Robinson KS, Mangan MSJ, De Graaf D, Shkarina K, Lovotti M, Standke L, Kaiser R, Stahl R, Duthie FG, Rothe M, Antonova K, Jenster LM, Lau ZH, Rösing S, Mirza N, Gottschild C, Wachten D, Günther C, Kufer TA, Schmidt FI, Zhong FL, Latz E.

Nat Immunol. 2023 Apr;24(4):595-603.

Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever

Mangan MSJ, Gorki F, Krause K, Heinz A, Pankow A, Ebert T, Jahn D, Hiller K, Hornung V, Maurer M, Schmidt FI, Gerhard R, Latz E.

PLoS Biol. 2022 Nov 7;20(11):e3001351

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

Lauterbach MA, Hanke JE, Serefidou M, Mangan MSJ, Kolbe CC, Hess T, Rothe M, Kaiser R, Hoss F, Gehlen J, Engels G, Kreutzenbeck M, Schmidt SV, Christ A, Imhof A, Hiller K, Latz E.

Immunity. 2019 Dec 17;51(6):997-1011.e7. doi: 10.1016/j.immuni.2019.11.009.

Alternative splicing regulates stochastic NLRP3 activity

Hoss F, Mueller JL, Rojas Ringeling F, Rodriguez-Alcazar JF, Brinkschulte R, Seifert G, Stahl R, Broderick L, Putnam CD, Kolodner RD, Canzar S, Geyer M, Hoffman HM, Latz E.

Nat Commun. 2019 Jul 19;10(1):3238. doi: 10.1038/s41467-019-11076-1.

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

Christ A, Günther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, Scholz CJ, Oosting M, Haendler K, Baßler K, Klee K, Schulte-Schrepping J, Ulas T, Moorlag SJCFM, Kumar V, Park MH, Joosten LAB, Groh LA, Riksen NP, Espevik T, Schlitzer A, Li Y, Fitzgerald ML, Netea MG, Schultze JL, Latz E.

Cell. 2018 Jan 11;172(1-2):162-175.e14. doi: 10.1016/j.cell.2017.12.013.

The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport

Pelka K, Bertheloot D, Reimer E, Phulphagar K, Schmidt SV, Christ A, Stahl R, Watson N, Miyake K, Hacohen N, Haas A, Brinkmann MM, Marshak-Rothstein A, Meissner F, Latz E.

Immunity. 2018 May 15;48(5):911-922.e7. doi: 10.1016/j.immuni.2018.04.011.

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT.

Nature. 2017 Dec 20;552(7685):355-361. doi: 10.1038/nature25158.

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

Stutz A, Kolbe CC, Stahl R, Horvath GL, Franklin BS, van Ray O, Brinkschulte R, Geyer M, Meissner F, Latz E.

J Exp Med. 2017 Jun 5;214(6):1725-1736. doi: 10.1084/jem.20160933. Epub 2017 May 2.

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

Zimmer S, Grebe A, Bakke SS, Bode N, Halvorsen B, Ulas T, Skjelland M, De Nardo D, Labzin LI, Kerksiek A, Hempel C, Heneka MT, Hawxhurst V, Fitzgerald ML, Trebicka J, Björkhem I, Gustafsson JÅ, Westerterp M, Tall AR, Wright SD, Espevik T, Schultze JL, Nickenig G, Lütjohann D, Latz E.

Sci Transl Med. 2016 Apr 6;8(333):333ra50. doi: 10.1126/scitranslmed.aad6100.

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E.

Nat Immunol. 2014 Aug;15(8):727-37. doi: 10.1038/ni.2913. Epub 2014 Jun 22.

Selected Reviews

How location and cellular signaling combine to activate the NLRP3 inflammasome

Akbal A, Dernst A, Lovotti M, Mangan MSJ, McManus RM, Latz E.

Cell Mol Immunol. 2022 Nov;19(11):1201-1214

Defining trained immunity and its role in health and disease

Netea MG, Domínguez-Andrés J, Barreiro LB, Chavakis T, Divangahi M, Fuchs E, Joosten LAB, van der Meer JWM, Mhlanga MM, Mulder WJM, Riksen NP, Schlitzer A, Schultze JL, Stabell Benn C, Sun JC, Xavier RJ, Latz E.

Nat Rev Immunol. 2020 Jun;20(6):375-388. doi: 10.1038/s41577-020-0285-6. Epub 2020 Mar 4.

Western Diet and the Immune System: An Inflammatory Connection

Christ A, Lauterbach M, Latz E.

Immunity. 2019 Nov 19;51(5):794-811. doi: 10.1016/j.immuni.2019.09.020.

The Western lifestyle has lasting effects on metaflammation

Christ A, Latz E.

Nat Rev Immunol. 2019 May;19(5):267-268. doi: 10.1038/s41577-019-0156-1.

Targeting the NLRP3 inflammasome in inflammatory diseases

Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E.

Nat Rev Drug Discov. 2018 Aug;17(8):588-606. doi: 10.1038/nrd.2018.97. Epub 2018 Jul 20.

Inflammasome signalling in brain function and neurodegenerative disease

Heneka MT, McManus RM, Latz E.

Nat Rev Neurosci. 2018 Oct;19(10):610-621. doi: 10.1038/s41583-018-0055-7.

Innate Immunity and Neurodegeneration

Labzin LI, Heneka MT, Latz E.

Annu Rev Med. 2018 Jan 29;69:437-449. doi: 10.1146/annurev-med-050715-104343. Epub 2017 Nov 6.

Targeting the NLRP3 inflammasome in inflammatory diseases

Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E.

Nat Rev Drug Discov. 2018 Sep;17(9):688. doi: 10.1038/nrd.2018.149. Epub 2018 Aug 17.

A guiding map for inflammation

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA.

Nat Immunol. 2017 Jul 19;18(8):826-831. doi: 10.1038/ni.3790.

Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control

Próchnicki T, Latz E.

Cell Metab. 2017 Jul 5;26(1):71-93. doi: 10.1016/j.cmet.2017.06.018.

Institute of Innate Immunity
University Hospital Bonn
Biomedical Center (BMZ 2)
Building 12
2G
Venusberg-Campus 1
53127 Bonn, Germany

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