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Alternating 2'-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist
Hamm S, Latz E, Hangel D, Müller T, Yu P, Golenbock D, Sparwasser T, Wagner H, Bauer S.
Immunobiology. 2010 Jul;215(7):559-69. doi: 10.1016/j.imbio.2009.09.003. Epub 2009 Oct 25.
10.1016/j.imbio.2009.09.003