Latest publications of the Institute of Innate Immunity

Find all publications from institute members

Selected III publications

Dagmar Wachten Laboratory

Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.

Khani S, Topel H, Kardinal R, Tavanez AR, Josephrajan A, Larsen BDM, Gaudry MJ, Leyendecker P, Egedal NM, Güller AS, Stanic N, Ruppert PMM, Gaziano I, Hansmeier NR, Schmidt E, Klemm P, Vagliano LM, Stahl R, Duthie F, Krause JH, Bici A, Engelhard CA, Gohlke S, Frommolt P, Gnad T, Rada-Iglesias A, Pradas-Juni M, Schulz TJ, Wunderlich FT, Pfeifer A, Bartelt A, Jastroch M, Wachten D*, Kornfeld JW*.

Nat Metab. 2024 Jun;6(6):1053-1075
Felix Meissner Laboratory

Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3tm1Flv mice

Felix D Weiss, Yubell Alvarez, Farhad Shakeri, Anshupa Sahu, Petro Leka, Alesja Dernst, Jessika Rollheiser, Matilde Vasconcelos, Adriana Geraci, Fraser Duthie, Rainer Stahl, Hye Eun Lee, Anne-Kathrin Gellner, Andreas Buness, Eicke Latz, Felix Meissner

Cell Death Differ . 2024 Sep 17. doi: 10.1038/s41418-024-01379-2.
Bernardo Franklin Laboratory

Platelet transcription factors license the pro-inflammatory cytokine response of human monocytes

Ibrahim Hawwari #, Lukas Rossnagel #, Nathalia Rosero, Salie Maasewerd, Matilde B Vasconcelos, Marius Jentzsch, Agnieszka Demczuk, Lino L Teichmann, Lisa Meffert, Damien Bertheloot, Lucas S Ribeiro, Sebastian Kallabis, Felix Meissner, Moshe Arditi, Asli E Atici, Magali Noval Rivas, Bernardo S Franklin

EMBO Mol Med . 2024 Aug;16(8):1901-1929. doi: 10.1038/s44321-024-00093-3.
Florian Schmidt Laboratory

Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application

Lisa D J Schiffelers, Yonas M Tesfamariam, Lea-Marie Jenster, Stefan Diehl, Sophie C Binder, Sabine Normann, Jonathan Mayr, Steffen Pritzl, Elena Hagelauer, Anja Kopp, Assaf Alon, Matthias Geyer, Hidde L Ploegh, Florian I Schmidt

Nat Commun . 2024 Sep 26;15(1):8266. doi: 10.1038/s41467-024-52110-1.
Bernardo Franklin Laboratory

Platelet transcription factors license the proinflammatory cytokine response of human monocytes.

Ibrahim Hawwari, Lukas Rossnagel, Nathalia Rosero, Salie Maasewerd, Matilde B Vasconcelos, Marius Jentzsch, Agnieszka Demczuk, Lino L Teichmann, Lisa Meffert, Damien Bertheloot, Lucas S Ribeiro, Sebastian Kallabis, Felix Meissner, Moshe Arditi, Asli E Atici, Magali Noval Rivas, Bernardo S Franklin

Florian Schmidt Laboratory

P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

Jenster LM, Lange KE, Normann S, vom Hemdt A, Wuerth JD, Schiffelers LDJ, Tesfamariam YM, Gohr FN, Klein L, Kaltheuner IH, Ebner S, Lapp DJ, Mayer J, Moecking J, Ploegh HL, Latz E, Meissner F, Geyer M, Kümmerer BM, Schmidt FI

J Exp Med 2 January 2023; 220 (1): e20220837
Felix Meissner Laboratory

Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation

Swietlik JJ, Bärthel S, Falcomatà C, Fink D, Sinha A, Cheng J, Ebner S, Landgraf P, Dieterich DC, Daub H, Saur D, Meissner F

Nat Commun. 2023 May 8;14(1):2642.
Eicke Latz Laboratory

Mitochondrial damage activates the NLRP10 inflammasome.

Próchnicki T, Vasconcelos MB, Robinson KS, Mangan MSJ, De Graaf D, Shkarina K, Lovotti M, Standke L, Kaiser R, Stahl R, Duthie FG, Rothe M, Antonova K, Jenster LM, Lau ZH, Rösing S, Mirza N, Gottschild C, Wachten D, Günther C, Kufer TA, Schmidt FI, Zhong FL, Latz E.

Nat Immunol. 2023 Apr;24(4):595-603.
Roisin McManus Laboratory

NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro

Charlotte Braatz, Max P. Komes, Kishore Aravind Ravichandran, Matheus Garcia de Fragas, Angelika Griep, Stephanie Schwartz, Róisín M. McManus, Michael T. Heneka

J Neurochem 2023 Feb 17
Bernardo Franklin Laboratory

Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo

Bertheloot D, Wanderley CWS, Schneider AH, Schiffelers LDJ, Wuerth JD, Tödtmann JMP, Maasewerd S, Hawwari I, Duthie F, Rohland C, Ribeiro LS, Jenster LM, Rosero N, Tesfamariam YM, Cunha FQ, Schmidt FI, Franklin BS.

EMBO Mol Med . 2022 Jun 8;14(6):e15415. doi: 10.15252/emmm.202115415.
Dagmar Wachten Laboratory

A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation

Hansen JN, Kaiser F, Leyendecker P, Stüven B, Krause JH, Derakhshandeh F, Irfan J, Sroka TJ, Preval KM, Desai PB, Kraut M, Theis H, Drews AD, De-Domenico E, Händler K, Pazour GJ, Henderson DJP, Mick DU, Wachten D

EMBO Rep. 2022 Aug 3;23(8):e54315
Dagmar Wachten Laboratory

AdipoQ-a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro

Sieckmann K, Winnerling N, Huebecker M, Leyendecker P, Juliana Silva Ribeiro D, Gnad T, Pfeifer A, Wachten D, Hansen JN

Mol Biol Cell. 2022 Oct 1;33(12):br22
Eicke Latz Laboratory

Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever

Mangan MSJ, Gorki F, Krause K, Heinz A, Pankow A, Ebert T, Jahn D, Hiller K, Hornung V, Maurer M, Schmidt FI, Gerhard R, Latz E.

PLoS Biol. 2022 Nov 7;20(11):e3001351
Roisin McManus Laboratory

Soluble TAM receptors predict structural and functional protection in pre-clinical Alzheimer´s disease

Brosseron F, A Maass, L Kleineidem, KA Ravichandran, PG González, RM McManus, C Ising, F Santarelli, CC Kolbe, LM Häsler, S Wolfsgruber, M Marquié, M Boada, A Orellana, I de Rojas, S Röske, O Peters, N Cosma, A Cetindag, T Özdogan, J Priller, EJ Spruth, S Altenstein, A Schneider, K Fliessbach, J Wiltfang, B Schott, K Bürger, M Dichgans, R Perneczky, BS Rauchmann, S Teipel, I Kilimann, D Göerß, C Laske, MH Munk, E Düzel, R Yakupow, L Dobisch, CD Metzger, W Glanz, M Ewers, P Dechent, JD Haynes, K Scheffler, N Roy, A Rostamzadeh, NL Marchant, A Spottke, M Jucker, E Latz, M Wagner, D Mengel, M Synofzik, F Jessen, A Ramirez, A Ruiz, MT Heneka and the DELCODE study group

Neuron 2022 Mar 16;110(6):1009-1022.e4.
Felix Meissner Laboratory

Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis

Phulphagar K, Kühn LI, Ebner S, Frauenstein A, Swietlik JJ, Rieckmann J, Meissner F.

Cell Rep. 2021 Mar 9;34(10):108826. doi: 10.1016/j.celrep.2021.108826.
Florian Schmidt Laboratory

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI.

Science. 2021 Feb 12;371(6530):eabe6230. doi: 10.1126/science.abe6230. Epub 2021 Jan 12.
Felix Meissner Laboratory

Identification of covalent modifications regulating immune signaling complex composition and phenotype

Frauenstein A, Ebner S, Hansen FM, Sinha A, Phulphagar K, Swatek K, Hornburg D, Mann M, Meissner F

Mol Syst Biol. 2021 Jul;17(7):e10125
Michael Heneka Laboratory

Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

Hannah Scheiblich, Cira Dansokho, Dilek Mercan, Susanne V Schmidt, Luc Bousset, Lena Wischhof, Frederik Eikens, Alexandru Odainic, Jasper Spitzer, Angelika Griep, Stephanie Schwartz, Daniele Bano, Eicke Latz, Ronald Melki, Michael T Heneka

Dagmar Wachten Laboratory

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

Hansen JN, Kaiser F, Klausen C, Stüven B, Chong R, Bönigk W, Mick DU, Möglich A, Jurisch-Yaksi N, Schmidt FI, Wachten D.

Elife. 2020 Jun 24;9:e57907. doi: 10.7554/eLife.57907.
Felix Meissner Laboratory

Quantitative and Dynamic Catalogs of Proteins Released during Apoptotic and Necroptotic Cell Death

Tanzer MC, Frauenstein A, Stafford CA, Phulphagar K, Mann M, Meissner F.

Cell Rep. 2020 Jan 28;30(4):1260-1270.e5. doi: 10.1016/j.celrep.2019.12.079.
Bernardo Franklin Laboratory

Platelets Fuel the Inflammasome Activation of Innate Immune Cells

Rolfes V, Ribeiro LS, Hawwari I, Böttcher L, Rosero N, Maasewerd S, Santos MLS, Próchnicki T, Silva CMS, Wanderley CWS, Rothe M, Schmidt SV, Stunden HJ, Bertheloot D, Rivas MN, Fontes CJ, Carvalho LH, Cunha FQ, Latz E, Arditi M, Franklin BS.

Cell Rep. 2020 May 12;31(6):107615. doi: 10.1016/j.celrep.2020.107615.
Roisin McManus Laboratory

T cells in Alzheimer's disease: space invaders

McManus RM, Heneka MT

Lancet Neurol. 2020 Apr;19(4):285-287
Eicke Latz Laboratory

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

Lauterbach MA, Hanke JE, Serefidou M, Mangan MSJ, Kolbe CC, Hess T, Rothe M, Kaiser R, Hoss F, Gehlen J, Engels G, Kreutzenbeck M, Schmidt SV, Christ A, Imhof A, Hiller K, Latz E.

Immunity. 2019 Dec 17;51(6):997-1011.e7. doi: 10.1016/j.immuni.2019.11.009.
Eicke Latz Laboratory

Alternative splicing regulates stochastic NLRP3 activity

Hoss F, Mueller JL, Rojas Ringeling F, Rodriguez-Alcazar JF, Brinkschulte R, Seifert G, Stahl R, Broderick L, Putnam CD, Kolodner RD, Canzar S, Geyer M, Hoffman HM, Latz E.

Nat Commun. 2019 Jul 19;10(1):3238. doi: 10.1038/s41467-019-11076-1.
Roisin McManus Laboratory

NLRP3 inflammasome activation drives Tau pathology

Ising C, C Venegas, S Zhang, H Scheiblich, SV Schmidt, A Vieira-Saeker, S Schwartz, S Albasset, RM McManus, D Tejera, A Griep, F Santarelli, F Brosseron, S Opitz, J Stunden, M Merten, R Kayed, DT Golenbock, D Blum, E Latz, L Buée, MT Heneka.

Nature 2019 Nov;575(7784):669-673
Eicke Latz Laboratory

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

Christ A, Günther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, Scholz CJ, Oosting M, Haendler K, Baßler K, Klee K, Schulte-Schrepping J, Ulas T, Moorlag SJCFM, Kumar V, Park MH, Joosten LAB, Groh LA, Riksen NP, Espevik T, Schlitzer A, Li Y, Fitzgerald ML, Netea MG, Schultze JL, Latz E.

Cell. 2018 Jan 11;172(1-2):162-175.e14. doi: 10.1016/j.cell.2017.12.013.
Eicke Latz Laboratory

The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport

Pelka K, Bertheloot D, Reimer E, Phulphagar K, Schmidt SV, Christ A, Stahl R, Watson N, Miyake K, Hacohen N, Haas A, Brinkmann MM, Marshak-Rothstein A, Meissner F, Latz E.

Immunity. 2018 May 15;48(5):911-922.e7. doi: 10.1016/j.immuni.2018.04.011.
Felix Meissner Laboratory

EASI-tag enables accurate multiplexed and interference-free MS2-based proteome quantification

Virreira Winter S, Meier F, Wichmann C, Cox J, Mann M, Meissner F.

Nat Methods. 2018 Jul;15(7):527-530. doi: 10.1038/s41592-018-0037-8. Epub 2018 Jun 18.
Florian Schmidt Laboratory

Phenotypic Lentivirus Screens to Identify Antiviral Single Domain Antibodies

Schmidt FI.

Methods Mol Biol. 2018;1836:139-158. doi: 10.1007/978-1-4939-8678-1_7.
Eicke Latz Laboratory

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT.

Nature. 2017 Dec 20;552(7685):355-361. doi: 10.1038/nature25158.
Eicke Latz Laboratory

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

Stutz A, Kolbe CC, Stahl R, Horvath GL, Franklin BS, van Ray O, Brinkschulte R, Geyer M, Meissner F, Latz E.

J Exp Med. 2017 Jun 5;214(6):1725-1736. doi: 10.1084/jem.20160933. Epub 2017 May 2.
Felix Meissner Laboratory

Social network architecture of human immune cells unveiled by quantitative proteomics

Rieckmann JC, Geiger R, Hornburg D, Wolf T, Kveler K, Jarrossay D, Sallusto F, Shen-Orr SS, Lanzavecchia A, Mann M, Meissner F.

Nat Immunol. 2017 May;18(5):583-593. doi: 10.1038/ni.3693. Epub 2017 Mar 6.
Eicke Latz Laboratory

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

Zimmer S, Grebe A, Bakke SS, Bode N, Halvorsen B, Ulas T, Skjelland M, De Nardo D, Labzin LI, Kerksiek A, Hempel C, Heneka MT, Hawxhurst V, Fitzgerald ML, Trebicka J, Björkhem I, Gustafsson JÅ, Westerterp M, Tall AR, Wright SD, Espevik T, Schultze JL, Nickenig G, Lütjohann D, Latz E.

Sci Transl Med. 2016 Apr 6;8(333):333ra50. doi: 10.1126/scitranslmed.aad6100.
Dagmar Wachten Laboratory

A novel biosensor to study cAMP dynamics in cilia and flagella

Mukherjee S, Jansen V, Jikeli JF, Hamzeh H, Alvarez L, Dombrowski M, Balbach M, Strünker T, Seifert R, Kaupp UB, Wachten D.

Elife. 2016 Mar 22;5:e14052. doi: 10.7554/eLife.14052.
Dagmar Wachten Laboratory

Controlling fertilization and cAMP signaling in sperm by optogenetics

Jansen V, Alvarez L, Balbach M, Strünker T, Hegemann P, Kaupp UB, Wachten D.

Elife. 2015 Jan 20;4:e05161. doi: 10.7554/eLife.05161.
Eicke Latz Laboratory

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E.

Nat Immunol. 2014 Aug;15(8):727-37. doi: 10.1038/ni.2913. Epub 2014 Jun 22.
Eicke Latz Laboratory

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3

De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M, Xu D, Zimmer S, Lahrmann C, Schildberg FA, Vogelhuber J, Kraut M, Ulas T, Kerksiek A, Krebs W, Bode N, Grebe A, Fitzgerald ML, Hernandez NJ, Williams BR, Knolle P, Kneilling M, Röcken M, Lütjohann D, Wright SD, Schultze JL, Latz E.

Nat Immunol. 2014 Feb;15(2):152-60. doi: 10.1038/ni.2784. Epub 2013 Dec 8.
Bernardo Franklin Laboratory

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E.

Nat Immunol. 2014 Aug;15(8):727-37. doi: 10.1038/ni.2913. Epub 2014 Jun 22.
Roisin McManus Laboratory

Respiratory infection promotes T cell infiltration and amyloid-beta deposition in APP/PS1 mice

Róisín M McManus, Sarah C Higgins, Kingston H G Mills, Marina A Lynch

Neurobiol Aging 2014 Jan;35(1):109-21.
Roisin McManus Laboratory

Respiratory infection promotes T cell infiltration and amyloid-beta deposition in APP/PS1 mice

McManus RM, SC Higgins, KH Mills, MA Lynch

Neurobiol Aging. 2014 Jan;35(1):109-21
Eicke Latz Laboratory

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT.

Nature. 2013 Jan 31;493(7434):674-8. doi: 10.1038/nature11729. Epub 2012 Dec 19.
Eicke Latz Laboratory

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

Ablasser A, Schmid-Burgk JL, Hemmerling I, Horvath GL, Schmidt T, Latz E, Hornung V.

Nature. 2013 Nov 28;503(7477):530-4. doi: 10.1038/nature12640. Epub 2013 Sep 29.
Eicke Latz Laboratory

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA

Sirois CM, Jin T, Miller AL, Bertheloot D, Nakamura H, Horvath GL, Mian A, Jiang J, Schrum J, Bossaller L, Pelka K, Garbi N, Brewah Y, Tian J, Chang C, Chowdhury PS, Sims GP, Kolbeck R, Coyle AJ, Humbles AA, Xiao TS, Latz E.

J Exp Med. 2013 Oct 21;210(11):2447-63. doi: 10.1084/jem.20120201. Epub 2013 Sep 30.
Eicke Latz Laboratory

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nuñez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E.

Nature. 2010 Apr 29;464(7293):1357-61. doi: 10.1038/nature08938.
Eicke Latz Laboratory

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA.

Nature. 2009 Mar 26;458(7237):514-8. doi: 10.1038/nature07725. Epub 2009 Jan 21.
Eicke Latz Laboratory

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT.

Nat Immunol. 2008 Aug;9(8):857-65. doi: 10.1038/ni.1636. Epub 2008 Jul 11.
Eicke Latz Laboratory

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E.

Nat Immunol. 2008 Aug;9(8):847-56. doi: 10.1038/ni.1631. Epub 2008 Jul 11.
Eicke Latz Laboratory

Ligand-induced conformational changes allosterically activate Toll-like receptor 9

Latz E, Verma A, Visintin A, Gong M, Sirois CM, Klein DC, Monks BG, McKnight CJ, Lamphier MS, Duprex WP, Espevik T, Golenbock DT.

Nat Immunol. 2007 Jul;8(7):772-9. doi: 10.1038/ni1479. Epub 2007 Jun 17.
Eicke Latz Laboratory

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

Latz E, Schoenemeyer A, Visintin A, Fitzgerald KA, Monks BG, Knetter CF, Lien E, Nilsen NJ, Espevik T, Golenbock DT.

Nat Immunol. 2004 Feb;5(2):190-8. doi: 10.1038/ni1028. Epub 2004 Jan 11.
Eicke Latz Laboratory

NLRP3-mediated glutaminolysis regulates microglia in Alzheimer's disease

McManus RM, MP Komes, A Griep, F Santarelli, S Schwartz, JR Perea, MA Khalil, JCM Schlachetzki, DS Bouvier, M Lauterbach, L Heinemann, T Schlüter, M Shaban Pour, M Lovotti, R Stahl, F Duthie, JF Rodríguez-Alcázar, SV Schmidt, J Spitzer, P Noori, A Maillo, A Boettcher, B Herron, J McConville, D Gomez-Cabrero, J Tegnér, CK Glass, K Hiller, E Latz#, MT Heneka#

Selected III Reviews

Roisin McManus Laboratory

NLRP3 inflammasome signalling in Alzheimer's disease

Róisín M. McManus and Eicke Latz

Neuropharmacology 2024 Mar 31:252:109941
Dagmar Wachten Laboratory

The neuronal cilium - a highly diverse and dynamic organelle involved in sensory detection and neuromodulation

N. Jurisch-Yaksi, D. Wachten, J. Gopalakrishnan

Trends Neurosci . 2024 May;47(5):383-394.
Felix Meissner Laboratory

Landscape of protein-protein interactions during hepatitis C virus assembly and release

Alina Matthaei, Sebastian Joecks, Annika Frauenstein, Janina Bruening, Dorothea Bankwitz, Martina Friesland, Gisa Gerold, Gabrielle Vieyres, Lars Kaderali, Felix Meissner, Thomas Pietschmann

Microbiol Spectr . 2024 Feb 6;12(2):e0256222. doi: 10.1128/spectrum.02562-22
Bernardo Franklin Laboratory

Platelets in Kawasaki disease: mediators of vascular inflammation

Magali Noval Rivas, Begüm Kocatürk, Bernardo S Franklin, Moshe Arditi

Nat Rev Rheumatol . 2024 Aug;20(8):459-472. doi: 10.1038/s41584-024-01119-3.
Dagmar Wachten Laboratory

Emerging principles of primary cilia dynamics in controlling tissue organization and function

Gopalakrishnan J, Feistel K, Friedrich BM, Grapin-Botton A, Jurisch-Yaksi N, Mass E, Mick DU, Müller RU, May-Simera H, Schermer B, Schmidts M, Walentek P, Wachten D.

EMBO J. 2023 Nov 2;42(21):e113891.
Dagmar Wachten Laboratory

Primary cilia and their effects on immune cell functions and metabolism: a model

Ernesto Picon-Galindo, Eicke Latz, Dagmar Wachten,

Trends Immunol. 2022 May;43(5):366-378
Felix Meissner Laboratory

The Emerging Role of Mass Spectrometry-based Proteomics in Drug Discovery

Meissner F, Geddes-McAlister J, Mann M, Bantscheff M

Nat Rev Drug Discov. 2022 Sep;21(9):637-654
Eicke Latz Laboratory

How location and cellular signaling combine to activate the NLRP3 inflammasome

Akbal A, Dernst A, Lovotti M, Mangan MSJ, McManus RM, Latz E.

Cell Mol Immunol. 2022 Nov;19(11):1201-1214
Dagmar Wachten Laboratory

Signal transduction in primary cilia - analyzing and manipulating GPCR and second messenger signaling

Wachten D, Mick DU.

Pharmacol Ther. 2021 Aug;224:107836. doi: 10.1016/j.pharmthera.2021.107836
Dagmar Wachten Laboratory

The BBSome: a nexus controlling energy metabolism in the brain

Blaess S, Wachten D.

J Clin Invest. 2021 Apr 15;131(8):148903. doi: 10.1172/JCI148903.

Publications of institute members

Maintaining proteostasis under mechanical stress.

Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, Warscheid B

MBO Rep . 2021 Aug 4;22(8):e52507. doi: 10.15252/embr.202152507
Florian Schmidt Laboratory

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

Hayn M, Hirschenberger M, Koepke L, Nchioua R, Straub JH, Klute S, Hunszinger V, Zech F, Prelli Bozzo C, Aftab W, Christensen MH, Conzelmann C, Müller JA, Srinivasachar Badarinarayan S, Stürzel CM, Forne I, Stenger S, Conzelmann KK, Münch J, Schmidt FI, Sauter D, Imhof A, Kirchhoff F, Sparrer KMJ

Cell Rep. 2021 May 18;35(7):109126. doi: 10.1016/j.celrep.2021.109126. Epub 2021 Apr 27
Roisin McManus Laboratory

NLRP3 inflammasome signalling in Alzheimer's disease

Róisín M. McManus and Eicke Latz

Neuropharmacology 2024 Mar 31:252:109941
Dagmar Wachten Laboratory

Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.

Khani S, Topel H, Kardinal R, Tavanez AR, Josephrajan A, Larsen BDM, Gaudry MJ, Leyendecker P, Egedal NM, Güller AS, Stanic N, Ruppert PMM, Gaziano I, Hansmeier NR, Schmidt E, Klemm P, Vagliano LM, Stahl R, Duthie F, Krause JH, Bici A, Engelhard CA, Gohlke S, Frommolt P, Gnad T, Rada-Iglesias A, Pradas-Juni M, Schulz TJ, Wunderlich FT, Pfeifer A, Bartelt A, Jastroch M, Wachten D*, Kornfeld JW*.

Nat Metab. 2024 Jun;6(6):1053-1075
Dagmar Wachten Laboratory

The neuronal cilium - a highly diverse and dynamic organelle involved in sensory detection and neuromodulation

N. Jurisch-Yaksi, D. Wachten, J. Gopalakrishnan

Trends Neurosci . 2024 May;47(5):383-394.
Felix Meissner Laboratory

Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3tm1Flv mice

Felix D Weiss, Yubell Alvarez, Farhad Shakeri, Anshupa Sahu, Petro Leka, Alesja Dernst, Jessika Rollheiser, Matilde Vasconcelos, Adriana Geraci, Fraser Duthie, Rainer Stahl, Hye Eun Lee, Anne-Kathrin Gellner, Andreas Buness, Eicke Latz, Felix Meissner

Cell Death Differ . 2024 Sep 17. doi: 10.1038/s41418-024-01379-2.
Felix Meissner Laboratory

Landscape of protein-protein interactions during hepatitis C virus assembly and release

Alina Matthaei, Sebastian Joecks, Annika Frauenstein, Janina Bruening, Dorothea Bankwitz, Martina Friesland, Gisa Gerold, Gabrielle Vieyres, Lars Kaderali, Felix Meissner, Thomas Pietschmann

Microbiol Spectr . 2024 Feb 6;12(2):e0256222. doi: 10.1128/spectrum.02562-22
Bernardo Franklin Laboratory

Platelet transcription factors license the pro-inflammatory cytokine response of human monocytes

Ibrahim Hawwari #, Lukas Rossnagel #, Nathalia Rosero, Salie Maasewerd, Matilde B Vasconcelos, Marius Jentzsch, Agnieszka Demczuk, Lino L Teichmann, Lisa Meffert, Damien Bertheloot, Lucas S Ribeiro, Sebastian Kallabis, Felix Meissner, Moshe Arditi, Asli E Atici, Magali Noval Rivas, Bernardo S Franklin

EMBO Mol Med . 2024 Aug;16(8):1901-1929. doi: 10.1038/s44321-024-00093-3.
Bernardo Franklin Laboratory

Platelets in Kawasaki disease: mediators of vascular inflammation

Magali Noval Rivas, Begüm Kocatürk, Bernardo S Franklin, Moshe Arditi

Nat Rev Rheumatol . 2024 Aug;20(8):459-472. doi: 10.1038/s41584-024-01119-3.
Florian Schmidt Laboratory

Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application

Lisa D J Schiffelers, Yonas M Tesfamariam, Lea-Marie Jenster, Stefan Diehl, Sophie C Binder, Sabine Normann, Jonathan Mayr, Steffen Pritzl, Elena Hagelauer, Anja Kopp, Assaf Alon, Matthias Geyer, Hidde L Ploegh, Florian I Schmidt

Nat Commun . 2024 Sep 26;15(1):8266. doi: 10.1038/s41467-024-52110-1.
Bernardo Franklin Laboratory

Platelet transcription factors license the proinflammatory cytokine response of human monocytes.

Ibrahim Hawwari, Lukas Rossnagel, Nathalia Rosero, Salie Maasewerd, Matilde B Vasconcelos, Marius Jentzsch, Agnieszka Demczuk, Lino L Teichmann, Lisa Meffert, Damien Bertheloot, Lucas S Ribeiro, Sebastian Kallabis, Felix Meissner, Moshe Arditi, Asli E Atici, Magali Noval Rivas, Bernardo S Franklin

Bernardo Franklin Laboratory

"Cruising together"-ASC specks and SAA, a perfect match in chronic inflammation

Salie Maasewerd, Bernardo S Franklin

Maasewerd S, Franklin BS, EMBO Mol Med . 2024 Sep;16(9):1983-1985.
Florian Schmidt Laboratory

P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

Jenster LM, Lange KE, Normann S, vom Hemdt A, Wuerth JD, Schiffelers LDJ, Tesfamariam YM, Gohr FN, Klein L, Kaltheuner IH, Ebner S, Lapp DJ, Mayer J, Moecking J, Ploegh HL, Latz E, Meissner F, Geyer M, Kümmerer BM, Schmidt FI

J Exp Med 2 January 2023; 220 (1): e20220837
Felix Meissner Laboratory

Proteomics separates adult-type diffuse high-grade gliomas in metabolic subgroups independent of 1p/19q codeletion and across IDH mutational status

Bader JM, Deigendesch N, Misch M, Mann M, Koch A, Meissner F

Cell Rep Med. 2023 Jan 17;4(1):100877.
Eicke Latz Laboratory

Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study

Brosseron F, Maass A, Kleineidam L, Ravichandran KA, Kolbe CC, Wolfsgruber S, Santarelli F, Häsler LM, McManus R, Ising C, Röske S, Peters O, Cosma NC, Schneider LS, Wang X, Priller J, Spruth EJ, Altenstein S, Schneider A, Fliessbach K, Wiltfang J, Schott BH, Buerger K, Janowitz D, Dichgans M, Perneczky R, Rauchmann BS, Teipel S, Kilimann I, Görß D, Laske C, Munk MH, Düzel E, Yakupow R, Dobisch L, Metzger CD, Glanz W, Ewers M, Dechent P, Haynes JD, Scheffler K, Roy N, Rostamzadeh A, Spottke A, Ramirez A, Mengel D, Synofzik M, Jucker M, Latz E, Jessen F, Wagner M, Heneka MT; DELCODE study group.

Alzheimers Res Ther. 2023 Jan 12;15(1):13.
Dagmar Wachten Laboratory

Induced Remodelling of Astrocytes In Vitro and In Vivo by Manipulation of Astrocytic RhoA Activity

Domingos C, Müller FE, Passlick S, Wachten D, Ponimaskin E, Schwarz MK, Schoch S, Zeug A, Henneberger C.

Cells. 2023 Jan 15;12(2):331.
Eicke Latz Laboratory

Toll-like receptor-3 contributes to the development of aortic valve stenosis

Niepmann ST, Willemsen N, Boucher AS, Stei M, Goody P, Zietzer A, Bulic M, Billig H, Odainic A, Weisheit CK, Quast C, Adam M, Schmidt SV, Bakhtiary F, Jansen F, Nickenig G, Latz E, Zimmer S

Basic Res Cardiol. 2023 Feb 1;118(1):6.
Eicke Latz Laboratory

Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury

Hackstein CP, Spitzer J, Symeonidis K, Horvatic H, Bedke T, Steglich B, Klein S, Assmus LM, Odainic A, Szlapa J, Kessler N, Beyer M, Schmithausen R, Latz E, Flavell RA, Garbi N, Kurts C, Kümmerer BM, Trebicka J, Roers A, Huber S, Schmidt SV, Knolle PA, Abdullah Z

J Hepatol. 2023 Mar 2:S0168-8278(23)00158-7
Felix Meissner Laboratory

Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation

Swietlik JJ, Bärthel S, Falcomatà C, Fink D, Sinha A, Cheng J, Ebner S, Landgraf P, Dieterich DC, Daub H, Saur D, Meissner F

Nat Commun. 2023 May 8;14(1):2642.
Bernardo Franklin Laboratory

Platelets exacerbate cardiovascular inflammation in a murine model of Kawasaki disease vasculitis

Begüm Kocatürk, Youngho Lee, Nobuyuki Nosaka, Masanori Abe, Daisy Martinon, Malcolm E Lane, Debbie Moreira, Shuang Chen, Michael C Fishbein, Rebecca A Porritt, Bernardo S Franklin, Magali Noval Rivas, Moshe Arditi

Dagmar Wachten Laboratory

Emerging principles of primary cilia dynamics in controlling tissue organization and function

Gopalakrishnan J, Feistel K, Friedrich BM, Grapin-Botton A, Jurisch-Yaksi N, Mass E, Mick DU, Müller RU, May-Simera H, Schermer B, Schmidts M, Walentek P, Wachten D.

EMBO J. 2023 Nov 2;42(21):e113891.
Eicke Latz Laboratory

Mitochondrial damage activates the NLRP10 inflammasome.

Próchnicki T, Vasconcelos MB, Robinson KS, Mangan MSJ, De Graaf D, Shkarina K, Lovotti M, Standke L, Kaiser R, Stahl R, Duthie FG, Rothe M, Antonova K, Jenster LM, Lau ZH, Rösing S, Mirza N, Gottschild C, Wachten D, Günther C, Kufer TA, Schmidt FI, Zhong FL, Latz E.

Nat Immunol. 2023 Apr;24(4):595-603.
Roisin McManus Laboratory

NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro

Charlotte Braatz, Max P. Komes, Kishore Aravind Ravichandran, Matheus Garcia de Fragas, Angelika Griep, Stephanie Schwartz, Róisín M. McManus, Michael T. Heneka

J Neurochem 2023 Feb 17
Dagmar Wachten Laboratory

Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human

Simon Schneider , Andjela Kovacevic , Michelle Mayer , Ann-Kristin Dicke , Lena Arévalo , Sophie A Koser , Jan N Hansen , Samuel Young , Christoph Brenker , Sabine Kliesch , Dagmar Wachten , Gregor Kirfel , Timo Strünker , Frank Tüttelmann , Hubert Schorle

Elife . 2023 Nov 28:12:RP86100
Dagmar Wachten Laboratory

Primary cilia and their effects on immune cell functions and metabolism: a model

Ernesto Picon-Galindo, Eicke Latz, Dagmar Wachten,

Trends Immunol. 2022 May;43(5):366-378
Felix Meissner Laboratory

The Emerging Role of Mass Spectrometry-based Proteomics in Drug Discovery

Meissner F, Geddes-McAlister J, Mann M, Bantscheff M

Nat Rev Drug Discov. 2022 Sep;21(9):637-654
Michael Heneka Laboratory

p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function

Perea JR, Bolós M, Cuadros R, García E, García-Escudero V, Hernández F, McManus RM, Heneka MT, Avila J.

Mol Neurobiol. 2022 Jan 10. doi: 10.1007/s12035-021-02715-0. Online ahead of print.
Bernardo Franklin Laboratory

Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo

Bertheloot D, Wanderley CWS, Schneider AH, Schiffelers LDJ, Wuerth JD, Tödtmann JMP, Maasewerd S, Hawwari I, Duthie F, Rohland C, Ribeiro LS, Jenster LM, Rosero N, Tesfamariam YM, Cunha FQ, Schmidt FI, Franklin BS.

EMBO Mol Med . 2022 Jun 8;14(6):e15415. doi: 10.15252/emmm.202115415.
Bernardo Franklin Laboratory

Platelets supply p38 MAPK signaling that licenses pro-inflammatory cytokine responses of human monocytes

Ibrahim Hawwari, Nathalia Sofia Rosero Reyes, Lucas S. Ribeiro, Agnieszka Demczuk, Lino L Teichmann, Lisa Meffert, Damien Bertheloot, Bernardo S. Franklin

Eicke Latz Laboratory

How location and cellular signaling combine to activate the NLRP3 inflammasome

Akbal A, Dernst A, Lovotti M, Mangan MSJ, McManus RM, Latz E.

Cell Mol Immunol. 2022 Nov;19(11):1201-1214
Eicke Latz Laboratory

Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles

Hosen MR, Goody PR, Zietzer A, Xiang X, Niepmann ST, Sedaghat A, Tiyerili V, Chennupati R, Moore JB 4th, Boon RA, Uchida S, Sinning JM, Zimmer S, Latz E, Werner N, Nickenig G, Jansen F

Circulation. 2022 Dec 13;146(24):1836-1854
Eicke Latz Laboratory

Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever

Mangan MSJ, Gorki F, Krause K, Heinz A, Pankow A, Ebert T, Jahn D, Hiller K, Hornung V, Maurer M, Schmidt FI, Gerhard R, Latz E.

PLoS Biol. 2022 Nov 7;20(11):e3001351
Felix Meissner Laboratory

Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons

Riemenschneider H, Guo Q, Bader J, Frottin F, Farny D, Kleinberger G, Haass C, Mann M, Hartl FU, Baumeister W, Hipp MS, Meissner F, Fernández-Busnadiego R, Edbauer D.

EMBO Rep. 2022 Jun 7;23(6):e53890.
Felix Meissner Laboratory

Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment

Falcomatà C, Bärthel S, Widholz SA, Schneeweis C, Montero JJ, Toska A, Mir J, Kaltenbacher T, Heetmeyer J, Swietlik JJ, Cheng JY, Teodorescu B, Reichert O, Schmitt C, Grabichler K, Coluccio A, Boniolo F, Veltkamp C, Zukowska M, Vargas AA, Paik WH, Jesinghaus M, Steiger K, Maresch R, Öllinger R, Ammon T, Baranov O, Robles MS, Rechenberger J, Kuster B, Meissner F, Reichert M, Flossdorf M, Rad R, Schmidt-Supprian M, Schneider G, Saur D

Nat Cancer. 2022 Mar;3(3):318-336.
Felix Meissner Laboratory

Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity

Riera-Tur I, Schäfer T, Hornburg D, Mishra A, da Silva Padilha M, Fernández-Mosquera L, Feigenbutz D, Auer P, Mann M, Baumeister W, Klein R, Meissner F, Raimundo N, Fernández-Busnadiego R, Dudanova I

Life Sci Alliance. 2021 Dec 21;5(3):e202101185
Felix Meissner Laboratory

A Multi-Omics Approach Reveals Features That Permit Robust and Widespread Regulation of IFN-Inducible Antiviral Effectors

Göczi L, Csumita M, Horváth A, Nagy G, Póliska S, Pigni M, Thelemann C, Dániel B, Mianesaz H, Varga T, Sen K, Raghav SK, Schoggins JW, Nagy L, Acha-Orbea H, Meissner F, Reith W, Széles L

J Immunol. 2022 Nov 15;209(10):1930-1941
Felix Meissner Laboratory

Congenital deficiency reveals critical role of ISG15 in skin homeostasis

Malik MNH, Waqas SF, Zeitvogel J, Cheng J, Geffers R, Gouda ZA, Elsaman AM, Radwan AR, Schefzyk M, Braubach P, Auber B, Olmer R, Müsken M, Roesner LM, Gerold G, Schuchardt S, Merkert S, Martin U, Meissner F, Werfel T, Pessler F.

J Clin Invest. 2022 Feb 1;132(3):e141573
Dagmar Wachten Laboratory

Measurement of ciliary beating and fluid flow in the zebrafish adult telencephalon

Jeong I, Hansen JN, Wachten D, Jurisch-Yaksi N

STAR Protoc. 2022 Sep 16;3(3):101542. Epub 2022 Jul 16
Dagmar Wachten Laboratory

A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation

Hansen JN, Kaiser F, Leyendecker P, Stüven B, Krause JH, Derakhshandeh F, Irfan J, Sroka TJ, Preval KM, Desai PB, Kraut M, Theis H, Drews AD, De-Domenico E, Händler K, Pazour GJ, Henderson DJP, Mick DU, Wachten D

EMBO Rep. 2022 Aug 3;23(8):e54315
Dagmar Wachten Laboratory

AdipoQ-a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro

Sieckmann K, Winnerling N, Huebecker M, Leyendecker P, Juliana Silva Ribeiro D, Gnad T, Pfeifer A, Wachten D, Hansen JN

Mol Biol Cell. 2022 Oct 1;33(12):br22
Florian Schmidt Laboratory

Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus

Steiner A, Reygaerts T, Pontillo A, Ceccherini I, Moecking J, Moghaddas F, Davidson S, Caroli F, Grossi A, Castro FFM, Kalil J, Gohr FN, Schmidt FI, Bartok E, Zillinger T, Hartmann G, Geyer M, Gattorno M, Mendonça LO, Masters SL.

J Clin Immunol. 2022 Feb;42(2):325-335.
Eicke Latz Laboratory

Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever

Mangan MSJ, Gorki F, Krause K, Heinz A, Pankow A, Ebert T, Jahn D, Hiller K, Hornung V, Maurer M, Schmidt FI, Gerhard R, Latz E.

PLoS Biol. 2022 Nov 7;20(11):e3001351
Florian Schmidt Laboratory

Generation of an alpaca serum that induces immune-mediated crescentic glomerulonephritis in mice

Dhana E, Klaus D, Böhner A, Schmidt F, von Vietinghoff S, Boor P, Djudjaj S, Kurts C

Immunol Methods. 2022 Aug;507:113310
Eicke Latz Laboratory

Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production

Orecchioni M, Kobiyama K, Winkels H, Ghosheh Y, McArdle S, Mikulski Z, Kiosses WB, Fan Z, Wen L, Jung Y, Roy P, Ali AJ, Miyamoto Y, Mangan M, Makings J, Wang Z, Denn A, Vallejo J, Owens M, Durant CP, Braumann S, Mader N, Li L, Matsunami H, Eckmann L, Latz E, Wang Z, Hazen SL, Ley K

Science. 2022 Jan 14;375(6577):214-221.
Eicke Latz Laboratory

Immune response in COVID-19: what is next?

Li Q, Wang Y, Sun Q, Knopf J, Herrmann M, Lin L, Jiang J, Shao C, Li P, He X, Hua F, Niu Z, Ma C, Zhu Y, Ippolito G, Piacentini M, Estaquier J, Melino S, Weiss FD, Andreano E, Latz E, Schultze JL, Rappuoli R, Mantovani A, Mak TW, Melino G, Shi Y.

Cell Death Differ. 2022 Jun;29(6):1107-1122.
Eicke Latz Laboratory

Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3

Hochheiser IV, Pilsl M, Hagelueken G, Moecking J, Marleaux M, Brinkschulte R, Latz E, Engel C, Geyer M.

Nature. 2022 Apr;604(7904):184-189.
Eicke Latz Laboratory

Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19

Karagiannis F, Peukert K, Surace L, Michla M, Nikolka F, Fox M, Weiss P, Feuerborn C, Maier P, Schulz S, Al B, Seeliger B, Welte T, David S, Grondman I, de Nooijer AH, Pickkers P, Kleiner JL, Berger MM, Brenner T, Putensen C; Bonn COVIMMUNE Consortium; Kato H, Garbi N, Netea MG, Hiller K, Placek K, Bode C, Wilhelm C.

Nature. 2022 Sep;609(7928):801-807.
Bernardo Franklin Laboratory

Lysosomal cathepsins act in concert with Gasdermin-D during NAIP/NLRC4-dependent IL-1β secretion

Laura Migliari Branco , Marcelo Pires Amaral, Henning Boekhoff , Ana Beatriz Figueiredo de Lima, Ingrid Sancho Farias, Silvia Lucena Lage, Gustavo José Silva Pereira, Bernardo Simões Franklin, Karina Ramalho Bortoluci

Roisin McManus Laboratory

Soluble TAM receptors predict structural and functional protection in pre-clinical Alzheimer´s disease

Brosseron F, A Maass, L Kleineidem, KA Ravichandran, PG González, RM McManus, C Ising, F Santarelli, CC Kolbe, LM Häsler, S Wolfsgruber, M Marquié, M Boada, A Orellana, I de Rojas, S Röske, O Peters, N Cosma, A Cetindag, T Özdogan, J Priller, EJ Spruth, S Altenstein, A Schneider, K Fliessbach, J Wiltfang, B Schott, K Bürger, M Dichgans, R Perneczky, BS Rauchmann, S Teipel, I Kilimann, D Göerß, C Laske, MH Munk, E Düzel, R Yakupow, L Dobisch, CD Metzger, W Glanz, M Ewers, P Dechent, JD Haynes, K Scheffler, N Roy, A Rostamzadeh, NL Marchant, A Spottke, M Jucker, E Latz, M Wagner, D Mengel, M Synofzik, F Jessen, A Ramirez, A Ruiz, MT Heneka and the DELCODE study group

Neuron 2022 Mar 16;110(6):1009-1022.e4.
Eicke Latz Laboratory

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenwoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O'Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG.

Nat Immunol. 2021 Jan;22(1):2-6. doi: 10.1038/s41590-020-00845-6.
Eicke Latz Laboratory

Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury

Schneider KM, Elfers C, Ghallab A, Schneider CV, Galvez EJC, Mohs A, Gui W, Candels LS, Wirtz TH, Zuehlke S, Spiteller M, Myllys M, Roulet A, Ouzerdine A, Lelouvier B, Kilic K, Liao L, Nier A, Latz E, Bergheim I, Thaiss CA, Hengstler JG, Strowig T, Trautwein C.

Cell Mol Gastroenterol Hepatol. 2021;11(4):909-933. doi: 10.1016/j.jcmgh.2020.11.002. Epub 2020 Nov 12.
Eicke Latz Laboratory

Author Correction: A guiding map for inflammation

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA.

Nat Immunol. 2021 Feb;22(2):254. doi: 10.1038/s41590-020-00846-5.
Eicke Latz Laboratory

Bidirectional Role of NLRP3 During Acute and Chronic Cholestatic Liver Injury

Frissen M, Liao L, Schneider KM, Djudjaj S, Haybaeck J, Wree A, Rolle-Kampczyk U, von Bergen M, Latz E, Boor P, Trautwein C.

Hepatology. 2021 May;73(5):1836-1854. doi: 10.1002/hep.31494. Epub 2021 Mar 26.
Eicke Latz Laboratory

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

Bertheloot D, Latz E, Franklin BS.

Cell Mol Immunol. 2021 May;18(5):1106-1121. doi: 10.1038/s41423-020-00630-3. Epub 2021 Mar 30.
Eicke Latz Laboratory

Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid

Davanso MR, Crisma AR, Braga TT, Masi LN, do Amaral CL, Leal VNC, de Lima DS, Patente TA, Barbuto JA, Corrêa-Giannella ML, Lauterbach M, Kolbe CC, Latz E, Camara NOS, Pontillo A, Curi R.

Clin Sci (Lond). 2021 Jan 15;135(1):19-34. doi: 10.1042/CS20201348.
Eicke Latz Laboratory

Sensing soluble uric acid by Naip1-Nlrp3 platform

Braga TT, Davanso MR, Mendes D, de Souza TA, de Brito AF, Cruz MC, Hiyane MI, de Lima DS, Nunes V, de Fátima Giarola J, Souto DEP, Próchnicki T, Lauterbach M, Biscaia SMP, de Freitas RA, Curi R, Pontillo A, Latz E, Camara NOS.

Cell Death Dis. 2021 Feb 5;12(2):158. doi: 10.1038/s41419-021-03445-w.
Eicke Latz Laboratory

Interaction of TLR4 and TLR8 in the Innate Immune Response against Mycobacterium Tuberculosis

Thada S, Horvath GL, Müller MM, Dittrich N, Conrad ML, Sur S, Hussain A, Pelka K, Gaddam SL, Latz E, Slevogt H, Schumann RR, Burkert S.

Int J Mol Sci. 2021 Feb 4;22(4):1560. doi: 10.3390/ijms22041560.
Eicke Latz Laboratory

Inhibition of Caspase-1 with Tetracycline Ameliorates Acute Lung Injury

Peukert K, Fox M, Schulz S, Feuerborn C, Frede S, Putensen C, Wrigge H, Kümmerer BM, David S, Seeliger B, Welte T, Latz E, Klinman D, Wilhelm C, Steinhagen F, Bode C.

Am J Respir Crit Care Med. 2021 Mar 24. doi: 10.1164/rccm.202005-1916OC. Online ahead of print.
Eicke Latz Laboratory

Cytosolic D-type CpG-oligonucleotides induce a type i interferon response by activating the cGAS-STING signaling pathway

Bode C, Poth JM, Fox M, Schulz S, Klinman DM, Latz E, Steinhagen F.

Eur J Immunol. 2021 Apr 16. doi: 10.1002/eji.202048810. Online ahead of print.
Eicke Latz Laboratory

N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection

Shan D, Johnson JM, Fernandes SC, Suib H, Hwang S, Wuelfing D, Mendes M, Holdridge M, Burke EM, Beauregard K, Zhang Y, Cleary M, Xu S, Yao X, Patel PP, Plavina T, Wilson DH, Chang L, Kaiser KM, Nattermann J, Schmidt SV, Latz E, Hrusovsky K, Mattoon D, Ball AJ.

Nat Commun. 2021 Mar 26;12(1):1931. doi: 10.1038/s41467-021-22072-9.
Dagmar Wachten Laboratory

Signal transduction in primary cilia - analyzing and manipulating GPCR and second messenger signaling

Wachten D, Mick DU.

Pharmacol Ther. 2021 Aug;224:107836. doi: 10.1016/j.pharmthera.2021.107836
Dagmar Wachten Laboratory

Creld1 regulates myocardial development and function

Beckert V, Rassmann S, Kayvanjoo AH, Klausen C, Bonaguro L, Botermann DS, Krause M, Moreth K, Spielmann N, da Silva-Buttkus P, Fuchs H, Gailus-Durner V, de Angelis MH, Händler K, Ulas T, Aschenbrenner AC, Mass E, Wachten D.

J Mol Cell Cardiol . 2021 Jul;156:45-56. doi: 10.1016/j.yjmcc.2021.03.008. Epub 2021 Mar 24
Dagmar Wachten Laboratory

The BBSome: a nexus controlling energy metabolism in the brain

Blaess S, Wachten D.

J Clin Invest. 2021 Apr 15;131(8):148903. doi: 10.1172/JCI148903.
Dagmar Wachten Laboratory

CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images

Hansen JN, Rassmann S, Stüven B, Jurisch-Yaksi N, Wachten D.

Eur Phys J E Soft Matter. 2021 Mar 8;44(2):18. doi: 10.1140/epje/s10189-021-00031-y.
Felix Meissner Laboratory

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Pfister D, Núñez NG, Pinyol R, Govaere O, Pinter M, Szydlowska M, Gupta R, Qiu M, Deczkowska A, Weiner A, Müller F, Sinha A, Friebel E, Engleitner T, Lenggenhager D, Moncsek A, Heide D, Stirm K, Kosla J, Kotsiliti E, Leone V, Dudek M, Yousuf S, Inverso D, Singh I, Teijeiro A, Castet F, Montironi C, Haber PK, Tiniakos D, Bedossa P, Cockell S, Younes R, Vacca M, Marra F, Schattenberg JM, Allison M, Bugianesi E, Ratziu V, Pressiani T, D'Alessio A, Personeni N, Rimassa L, Daly AK, Scheiner B, Pomej K, Kirstein MM, Vogel A, Peck-Radosavljevic M, Hucke F, Finkelmeier F, Waidmann O, Trojan J, Schulze K, Wege H, Koch S, Weinmann A, Bueter M, Rössler F, Siebenhüner A, De Dosso S, Mallm JP, Umansky V, Jugold M, Luedde T, Schietinger A, Schirmacher P, Emu B, Augustin HG, Billeter A, Müller-Stich B, Kikuchi H, Duda DG, Kütting F, Waldschmidt DT, Ebert MP, Rahbari N, Mei HE, Schulz AR, Ringelhan M, Malek N, Spahn S, Bitzer M, Ruiz de Galarreta M, Lujambio A, Dufour JF, Marron TU, Kaseb A, Kudo M, Huang YH, Djouder N, Wolter K, Zender L, Marche PN, Decaens T, Pinato DJ, Rad R, Mertens JC, Weber A, Unger K, et al.

Nature. 2021 Apr;592(7854):450-456. doi: 10.1038/s41586-021-03362-0. Epub 2021 Mar 24.
Felix Meissner Laboratory

Interaction of 7SK with the Smn complex modulates snRNP production

Ji C, Bader J, Ramanathan P, Hennlein L, Meissner F, Jablonka S, Mann M, Fischer U, Sendtner M, Briese M.

Nat Commun. 2021 Feb 24;12(1):1278. doi: 10.1038/s41467-021-21529-1.
Felix Meissner Laboratory

Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis

Phulphagar K, Kühn LI, Ebner S, Frauenstein A, Swietlik JJ, Rieckmann J, Meissner F.

Cell Rep. 2021 Mar 9;34(10):108826. doi: 10.1016/j.celrep.2021.108826.
Bernardo Franklin Laboratory

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

Bertheloot D, Latz E, Franklin BS.

Cell Mol Immunol. 2021 May;18(5):1106-1121. doi: 10.1038/s41423-020-00630-3. Epub 2021 Mar 30.
Susanne Schmidt Laboratory

N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection

Shan D, Johnson JM, Fernandes SC, Suib H, Hwang S, Wuelfing D, Mendes M, Holdridge M, Burke EM, Beauregard K, Zhang Y, Cleary M, Xu S, Yao X, Patel PP, Plavina T, Wilson DH, Chang L, Kaiser KM, Nattermann J, Schmidt SV, Latz E, Hrusovsky K, Mattoon D, Ball AJ.

Nat Commun. 2021 Mar 26;12(1):1931. doi: 10.1038/s41467-021-22072-9.
Florian Schmidt Laboratory

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI.

Science. 2021 Feb 12;371(6530):eabe6230. doi: 10.1126/science.abe6230. Epub 2021 Jan 12.
Dagmar Wachten Laboratory

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility

Gadadhar S, Alvarez Viar G, Hansen JN, Gong A, Kostarev A, Ialy-Radio C, Leboucher S, Whitfield M, Ziyyat A, Touré A, Alvarez L, Pigino G, Janke C.

Science. 2021 Jan 8;371(6525):eabd4914. doi: 10.1126/science.abd4914.
Dagmar Wachten Laboratory

Cannabinoid receptor 1 signalling modulates stress susceptibility and microglial responses to chronic social defeat stress.

Beins EC, Beiert T, Jenniches I, Hansen JN, Leidmaa E, Schrickel JW, Zimmer A.

Transl Psychiatry. 2021 Mar 15;11(1):164. doi: 10.1038/s41398-021-01283-0
Bernardo Franklin Laboratory

The Interface Between Inflammatory Mediators and MicroRNAs in Plasmodium vivax Severe Thrombocytopenia

Santos, M.L.S., Coimbra, R.S., Sousa, T.N., Guimaraes, L.F.F., Gomes, M.S., Amaral, L.R., Pereira, D.B., Fontes, C.J.F., Hawwari, I., Franklin, B.S., Carvalho L.H.

Dagmar Wachten Laboratory

Results of a completely outpatient autologous stem cell transplant program for lymphoma patients receiving reduced-intensity conditioning.

Jaime-Pérez JC, Hernández-Coronado M, Picón-Galindo E, Salazar-Cavazos L, Gutiérrez-Aguirre CH, Gómez-Almaguer D.

Leuk Lymphoma. 2021 Jan 24:1-10. doi: 10.1080/10428194.2021.1876870.
Dagmar Wachten Laboratory

Maintaining proteostasis under mechanical stress

Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, Warscheid B.

EMBO Rep . 2021 Jul 26;e52507. doi: 10.15252/embr.202152507
Dagmar Wachten Laboratory

Multifocal imaging for precise, label-free tracking of fast biological processes in 3D

Hansen, JN, Gong, A, Wachten, D, Pascal, R, Turpin, A, Jikeli, JF, Kaup, UB, Alvarez, L

Nat Commun. 2021 Jul 28;12(1):4574. doi: 10.1038/s41467-021-24768-4
Eicke Latz Laboratory

Interrelations of Alzheimer´s disease candidate biomarkers neurogranin, fatty acid-binding protein 3 and ferritin to neurodegeneration and neuroinflammation

Brosseron F, Kleemann K, Kolbe CC, Santarelli F, Castro-Gomez S, Tacik P, Latz E, Jessen F, Heneka MT

J Neurochem . 2021 Jun;157(6):2210-2224. doi: 10.1111/jnc.15175. Epub 2020 Sep 18
Eicke Latz Laboratory

Regulation of ubiquitin and ubiquitin-like modifiers by phosphorylation

Hepowit NL, Kolbe CC, Zelle SR, Latz E, MacGurn JA

FEBS J . 2021 Jul 2. doi: 10.1111/febs.16101. Online ahead of print
Eicke Latz Laboratory

Development of Fluorescent and Biotin Probes Targeting NLRP3

Keuler T, Gatterdam K, Akbal A, Lovotti M, Marleaux M, Geyer M, Latz E, Gütschow M.

Front Chem. 2021 Apr 22;9:642273. doi: 10.3389/fchem.2021.642273.
Eicke Latz Laboratory

Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis

Bonnekoh H, Vera C, Abad-Perez A, Radetzki S, Neuenschwander M, Specker E, Mahnke NA, Frischbutter S, Latz E, Nazaré M, Kries JV, Maurer M, Scheffel J, Krause K

Clin Transl Allergy . 2021 Jul 22;11(5):e12045. doi: 10.1002/clt2.12045. eCollection 2021 Jul
Eicke Latz Laboratory

Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages.

Liu K, Sato R, Shibata T, Hiranuma R, Reuter T, Fukui R, Zhang Y, Ichinohe T, Ozawa M, Yoshida N, Latz E, Miyake K

Int Immunol. 2021 Jun 23:dxab033. doi: 10.1093/intimm/dxab033. Epub ahead of print
Eicke Latz Laboratory

Contact-dependent inhibition of HIV-1 replication in ex vivo human tonsil cultures by polymorphonuclear neutrophils

Reif T, Dyckhoff G, Hohenberger R, Kolbe CC, Gruell H, Klein F, Latz E, Stolp B, Fackler OT

Cell Rep Med . 2021 Jun 15;2(6):100317. doi: 10.1016/j.xcrm.2021.100317.
Eicke Latz Laboratory

Non-linear optical imaging of atherosclerotic plaques in the context of SIV and HIV infection prominently detects crystalline cholesterol esters.

Park MH, Suhalim JL, Elmastour F, Singha SK, Imafuku T, Venkatnarayan R, Christ A, Grebe A, Oppelt SA, Sviridov D, Bukrinsky M, Latz E, Potma EO, Fitzgerald ML

PLoS One. 2021 May 13;16(5):e0251599. doi: 10.1371/journal.pone.0251599
Eicke Latz Laboratory

Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenvoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O'Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG.

Nat Immunol . 2021 Jul;22(7):928. doi: 10.1038/s41590-021-00960-y
Dagmar Wachten Laboratory

Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization

Balbach M, Ghanem L, Rossetti T, Kaur N, Ritagliati C, Ferreira J, Krapf D, Molina LCP, Santi CM, Hansen JN, Wachten D, Fushimi M, Meinke PT, Buck J, Levin LR

Mol Hum Reprod . 2021 Aug 31;gaab054. doi: 10.1093/molehr/gaab054.
Dagmar Wachten Laboratory

Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function

Haward F, Maslon MM, Yeyati PL, Bellora N, Hansen JN, Aitken S, Lawson J, von Kriegsheim A, Wachten D, Mill P, Adams IR, Caceres JF

Elife. 2021 Aug 2;10:e65104. doi: 10.7554/eLife.65104
Susanne Schmidt Laboratory

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19

Krämer B, Knoll R, Bonaguro L, ToVinh M, Raabe J, Astaburuaga-García R, Schulte-Schrepping J, Kaiser KM, Rieke GJ, Bischoff J, Monin MB, Hoffmeister C, Schlabe S, De Domenico E, Reusch N, Händler K, Reynolds G, Blüthgen N, Hack G, Finnemann C, Nischalke HD, Strassburg CP, Stephenson E, Su Y, Gardner L, Yuan D, Chen D, Goldman J, Rosenstiel P, Schmidt SV, Latz E, Hrusovsky K, Ball AJ, Johnson JM, Koenig PA, Schmidt FI, Haniffa M, Heath JR, Kümmerer BM, Keitel V, Jensen B, Stubbemann P, Kurth F, Sander LE, Sawitzki B

Immunity. 2021 Nov 9;54(11):2650-2669.e14.
Dagmar Wachten Laboratory

Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain.

D'Gama PP, Qiu T, Cosacak MI, Rayamajhi D, Konac A, Hansen JN, Ringers C, Acuña-Hinrichsen F, Hui SP, Olstad EW, Chong YL, Lim CKA, Gupta A, Ng CP, Nilges BS, Kashikar ND, Wachten D, Liebl D, Kikuchi K, Kizil C, Yaksi E, Roy S, Jurisch-Yaksi N

Cell Rep. 2021 Oct 5;37(1):109775
Dagmar Wachten Laboratory

Simultaneous recording of multiple cellular signaling events by frequency- and spectrally-tuned multiplexing of fluorescent probes

Kierzek M, Deal PE, Miller EW, Mukherjee S, Wachten D, Baumann A, Kaupp UB, Strünker T, Brenker C.

Elife. 2021 Dec 3;10:e63129. doi: 10.7554/eLife.63129. Epub ahead of print.
Felix Meissner Laboratory

Identification of covalent modifications regulating immune signaling complex composition and phenotype

Frauenstein A, Ebner S, Hansen FM, Sinha A, Phulphagar K, Swatek K, Hornburg D, Mann M, Meissner F

Mol Syst Biol. 2021 Jul;17(7):e10125
Michael Heneka Laboratory

Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

Hannah Scheiblich, Cira Dansokho, Dilek Mercan, Susanne V Schmidt, Luc Bousset, Lena Wischhof, Frederik Eikens, Alexandru Odainic, Jasper Spitzer, Angelika Griep, Stephanie Schwartz, Daniele Bano, Eicke Latz, Ronald Melki, Michael T Heneka

Michael Heneka Laboratory

Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies

Hannah Scheiblich, Luc Bousset, Stephanie Schwartz, Angelika Griep, Eicke Latz, Ronald Melki, Michael T Heneka

Florian Schmidt Laboratory

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19

Krämer B, Knoll R, Bonaguro L, ToVinh M, Raabe J, Astaburuaga-García R, Schulte-Schrepping J, Kaiser KM, Rieke GJ, Bischoff J, Monin MB, Hoffmeister C, Schlabe S, De Domenico E, Reusch N, Händler K, Reynolds G, Blüthgen N, Hack G, Finnemann C, Nischalke HD, Strassburg CP, Stephenson E, Su Y, Gardner L, Yuan D, Chen D, Goldman J, Rosenstiel P, Schmidt SV, Latz E, Hrusovsky K, Ball AJ, Johnson JM, Koenig PA, Schmidt FI, Haniffa M, Heath JR, Kümmerer BM, Keitel V, Jensen B, Stubbemann P, Kurth F, Sander LE, Sawitzki B

Immunity. 2021 Nov 9;54(11):2650-2669.e14.
Eicke Latz Laboratory

Immediate and long-term consequences of COVID-19 infections for the development of neurological disease

Heneka MT, Golenbock D, Latz E, Morgan D, Brown R.

Alzheimers Res Ther. 2020 Jun 4;12(1):69. doi: 10.1186/s13195-020-00640-3.
Eicke Latz Laboratory

Defining trained immunity and its role in health and disease

Netea MG, Domínguez-Andrés J, Barreiro LB, Chavakis T, Divangahi M, Fuchs E, Joosten LAB, van der Meer JWM, Mhlanga MM, Mulder WJM, Riksen NP, Schlitzer A, Schultze JL, Stabell Benn C, Sun JC, Xavier RJ, Latz E.

Nat Rev Immunol. 2020 Jun;20(6):375-388. doi: 10.1038/s41577-020-0285-6. Epub 2020 Mar 4.
Eicke Latz Laboratory

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, Klug M, Schunk SJ, Schmit D, Kramann R, Körbel C, Ampofo E, Laschke MW, Selejan SR, Paschen A, Herter T, Schuster S, Silbernagel G, Sester M, Sester U, Aßmann G, Bals R, Kostner G, Jahnen-Dechent W, Menger MD, Rohrer L, März W, Böhm M, Jankowski J, Kopf M, Latz E, Niemeyer BA, Fliser D, Laufs U, Speer T.

Nat Immunol. 2020 Jan;21(1):30-41. doi: 10.1038/s41590-019-0548-1. Epub 2019 Dec 9.
Eicke Latz Laboratory

Platelets Fuel the Inflammasome Activation of Innate Immune Cells

Rolfes V, Ribeiro LS, Hawwari I, Böttcher L, Rosero N, Maasewerd S, Santos MLS, Próchnicki T, Silva CMS, Wanderley CWS, Rothe M, Schmidt SV, Stunden HJ, Bertheloot D, Rivas MN, Fontes CJ, Carvalho LH, Cunha FQ, Latz E, Arditi M, Franklin BS.

Cell Rep. 2020 May 12;31(6):107615. doi: 10.1016/j.celrep.2020.107615.
Eicke Latz Laboratory

β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia

Friker LL, Scheiblich H, Hochheiser IV, Brinkschulte R, Riedel D, Latz E, Geyer M, Heneka MT.

Cell Rep. 2020 Mar 17;30(11):3743-3754.e6. doi: 10.1016/j.celrep.2020.02.025.
Eicke Latz Laboratory

STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

Balic JJ, Albargy H, Luu K, Kirby FJ, Jayasekara WSN, Mansell F, Garama DJ, De Nardo D, Baschuk N, Louis C, Humphries F, Fitzgerald K, Latz E, Gough DJ, Mansell A.

Nat Commun. 2020 Jul 30;11(1):3816. doi: 10.1038/s41467-020-17669-5.
Eicke Latz Laboratory

Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection

Selkrig J, Li N, Hausmann A, Mangan MSJ, Zietek M, Mateus A, Bobonis J, Sueki A, Imamura H, El Debs B, Sigismondo G, Florea BI, Overkleeft HS, Kopitar-Jerala N, Turk B, Beltrao P, Savitski MM, Latz E, Hardt WD, Krijgsveld J, Typas A.

Nat Microbiol. 2020 Sep;5(9):1119-1133. doi: 10.1038/s41564-020-0736-7. Epub 2020 Jun 8.

Institute of Innate Immunity
University Hospital Bonn
Biomedical Center (BMZ 2)
Building 12
2G
Venusberg-Campus 1
53127 Bonn, Germany

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