McManus laboratory

Microglial Immunometabolism

Project details

The growing field of immunometabolism has shown that metabolic intermediates are central to controlling inflammation and immunity. Specifically, targeting metabolism has become a major interest in re-programming macrophages in diseases such as cancer, with compounds in clinical trials and some already with FDA approval. However, the role of immunometabolism in microglia is not understood. Within this project, we examine how immune signaling can affect the levels of different metabolites from the Krebs/TCA cycle, and the resulting impact on microglial function in health and disease-conditions.

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Project-related publications

NLRP3-mediated glutaminolysis regulates microglia in Alzheimer's disease

McManus RM, MP Komes, A Griep, F Santarelli, S Schwartz, JR Perea, MA Khalil, JCM Schlachetzki, DS Bouvier, M Lauterbach, L Heinemann, T Schlüter, M Shaban Pour, M Lovotti, R Stahl, F Duthie, JF Rodríguez-Alcázar, SV Schmidt, J Spitzer, P Noori, A Maillo, A Boettcher, B Herron, J McConville, D Gomez-Cabrero, J Tegnér, CK Glass, K Hiller, E Latz#, MT Heneka#