Eicke Latz Lab Publications

ScienceTeamPublicationsAlumni

All Publications

Selected publications

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3

De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M, Xu D, Zimmer S, Lahrmann C, Schildberg FA, Vogelhuber J, Kraut M, Ulas T, Kerksiek A, Krebs W, Bode N, Grebe A, Fitzgerald ML, Hernandez NJ, Williams BR, Knolle P, Kneilling M, Röcken M, Lütjohann D, Wright SD, Schultze JL, Latz E.

Nat Immunol. 2014 Feb;15(2):152-60. doi: 10.1038/ni.2784. Epub 2013 Dec 8.

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT.

Nature. 2013 Jan 31;493(7434):674-8. doi: 10.1038/nature11729. Epub 2012 Dec 19.

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

Ablasser A, Schmid-Burgk JL, Hemmerling I, Horvath GL, Schmidt T, Latz E, Hornung V.

Nature. 2013 Nov 28;503(7477):530-4. doi: 10.1038/nature12640. Epub 2013 Sep 29.

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA

Sirois CM, Jin T, Miller AL, Bertheloot D, Nakamura H, Horvath GL, Mian A, Jiang J, Schrum J, Bossaller L, Pelka K, Garbi N, Brewah Y, Tian J, Chang C, Chowdhury PS, Sims GP, Kolbeck R, Coyle AJ, Humbles AA, Xiao TS, Latz E.

J Exp Med. 2013 Oct 21;210(11):2447-63. doi: 10.1084/jem.20120201. Epub 2013 Sep 30.

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nuñez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E.

Nature. 2010 Apr 29;464(7293):1357-61. doi: 10.1038/nature08938.

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA.

Nature. 2009 Mar 26;458(7237):514-8. doi: 10.1038/nature07725. Epub 2009 Jan 21.

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT.

Nat Immunol. 2008 Aug;9(8):857-65. doi: 10.1038/ni.1636. Epub 2008 Jul 11.

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E.

Nat Immunol. 2008 Aug;9(8):847-56. doi: 10.1038/ni.1631. Epub 2008 Jul 11.

Ligand-induced conformational changes allosterically activate Toll-like receptor 9

Latz E, Verma A, Visintin A, Gong M, Sirois CM, Klein DC, Monks BG, McKnight CJ, Lamphier MS, Duprex WP, Espevik T, Golenbock DT.

Nat Immunol. 2007 Jul;8(7):772-9. doi: 10.1038/ni1479. Epub 2007 Jun 17.

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

Latz E, Schoenemeyer A, Visintin A, Fitzgerald KA, Monks BG, Knetter CF, Lien E, Nilsen NJ, Espevik T, Golenbock DT.

Nat Immunol. 2004 Feb;5(2):190-8. doi: 10.1038/ni1028. Epub 2004 Jan 11.

Selected Reviews

Trained immunity: A program of innate immune memory in health and disease

Netea MG, Joosten LA, Latz E, Mills KH, Natoli G, Stunnenberg HG, O'Neill LA, Xavier RJ.

Science. 2016 Apr 22;352(6284):aaf1098. doi: 10.1126/science.aaf1098. Epub 2016 Apr 21.

Crystal Formation in Inflammation

Franklin BS, Mangan MS, Latz E.

Annu Rev Immunol. 2016 May 20;34:173-202. doi: 10.1146/annurev-immunol-041015-055539. Epub 2016 Jan 11.

Nucleic acid-sensing TLRs and autoimmunity: novel insights from structural and cell biology

Pelka K, Shibata T, Miyake K, Latz E.

Immunol Rev. 2016 Jan;269(1):60-75. doi: 10.1111/imr.12375.

Innate immunity in Alzheimer's disease

Heneka MT, Golenbock DT, Latz E.

Nat Immunol. 2015 Mar;16(3):229-36. doi: 10.1038/ni.3102.

The inflammasomes and autoinflammatory syndromes

Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E.

Annu Rev Pathol. 2015;10:395-424. doi: 10.1146/annurev-pathol-012414-040431. Epub 2014 Nov 19.

Innate immune activation in neurodegenerative disease

Heneka MT, Kummer MP, Latz E.

Nat Rev Immunol. 2014 Jul;14(7):463-77. doi: 10.1038/nri3705.

Activation and regulation of the inflammasomes

Latz E, Xiao TS, Stutz A.

Nat Rev Immunol. 2013 Jun;13(6):397-411. doi: 10.1038/nri3452.

Intracellular DNA recognition

Hornung V, Latz E.

Nat Rev Immunol. 2010 Feb;10(2):123-30. doi: 10.1038/nri2690.

Institute of Innate Immunity
University Hospital Bonn
Biomedical Center (BMZ 2)
Building 12
2G
Venusberg-Campus 1
53127 Bonn, Germany

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